The current projects of the MRL fall into three groups:

• Mitochondrial disorders in the SA population: molecular genetics and metabolomics

  • Cohort investigations with national and international researchers and clinicians

• Adaptive responses in mitochondrial dysfunction

  • Metabolomics of mitochondrial deficiency using mouse models

  • Metallothionein expression in mitochondrial deficiency using mouse models

• Mitochondrial dysfunction in non-communicable diseases

  • Metabolomics of cardiovascular disease;

  • mtDNA involvement in cardiovascular disease, chronic fatigue syndrome and neurodegenerative diseases;

  • Oxidative stress and biotransformation involvement in oestrogen metabolism and its role in cancer development.