The Laboratory for Applied Molecular Modelling (LAMM) was established in 2001 as an initiative of Prof Dolf Bruinsma, Prof Manie Vosloo and Dr Gerhard Lachman. In 2002 Prof Cornie van Sittert joined this effort.  The primary aim of the LAMM initially was to give fundamental training to BSc Hons students in Chemistry, and training of senior students and academic staff interested in using molecular modelling in their research.  Over time, its offerings expanded to include software installation, registration support at the Centre of High-Performance Computing, and support for researchers outside the North-West University. One of the LAMM’s significant accomplishments is developing an Introduction course for BSc Hons students, which has been successfully presented at various academic institutions and industries across South Africa and at Hawassa University in Ethiopia. The University of Pretoria and the University of Kwazulu-Natal (Pietermaritzburg) were assisted in developing similar courses. 

In 2019 the Applied Molecular Modelling research group was established.  However, due to the overlap between the work done in the LAMM and the Applied Molecular Modelling group these two entities was combined in 2022 under the name of the LAMM and the leadership of Prof Cornie van Sittert.