Service Delivery:

The biotransformation status of clinically referred patients is currently monitored as part of a Biotransformation test package offered by the Centre for Human Metabolomics at the North-West University. The purpose of these tests is to monitor the liver’s reaction to a number of challenge substances. In doing this, Phase I (functionalization) and Phase II (conjugation) reactions response to these challenge substances are tested. At the same time any abnormalities in these reactions and their effects on free radical metabolism are recorded. These tests have now been done on a routine basis from 2008.

Furthermore, we are in the process of developing a method for comprehensive profiling of hormones and especially biotransformation products of hormones. This analysis will be incorporated into the Biotransformation test package shortly. Furthermore, a new method has been implemented for the determination of telomere length – a key indicator of premature ageing.

Current research:

An exciting new development on our research front was the CANSA research grant which we have recently received.  The aim of this research is to investigate the influence of specific synthetic hormones on the biotransformation pathways, DNA adduct formation and the development of cancer.  

Our research currently focuses on the following topics:

• Biotransformation profiles and oxidative stress in patients suffering from Chronic Fatigue Syndrome

• Biotransformation Profiles and Oxidative Stress in Premenopausal Women using Combined Oral Contraceptives

• The Exposome and Telomere length

• Polymorphisms associated with Biotransformation Metabolism.