The current projects of the group fall within three topics:
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Mitochondrial disorders in the SA population: molecular genetics and metabolomics
- Cohort investigations with national and international researchers and clinicians
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Adaptive responses and treatment strategies in mitochondrial dysfunction
- Metabolomics and transcriptomics of mitochondrial deficiency using mouse, stem cell and C.elegans disease models
- Metabolic transporters and alternate pathways as treatment strategies
- Metallothionein expression in mitochondrial deficiency
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Mitochondrial dysfunction in non-communicable diseases
- Metabolomics of cardiovascular disease
- Mitochondrial toxicity of HIV as well as anti-retroviral (ARV) treatment of HIV
- mtDNA involvement in cardiovascular disease, chronic fatigue syndrome and neurodegenerative diseases
- Oxidative stress and biotransformation involvement in oestrogen metabolism and its role in cancer development